Dr. McCord explains how Protandim activates Nrf2 pathways!
He goes into great detail about Nrf2 and what it does.
Download Protandim Transcription - 7 pages
Across the board with everyone who uses Protandim blood tests show (clinically via TBARS) that the cellular aging, known as Oxidative Stress, is reduced to that of a newborn baby or at the very least a small child. The results of using Protandim are staggering. Now I must tell you that this supplement, Protandim, is not an antioxidant or other form of a vitamin supplement that adds something to your body, no, Protandim works at the cellular level waking up your dormant "survival genes" which peak at about the age of 18-20 and decline rapidly there after. No matter what your age, 30, 50 or 80 yrs old, everyone gets similar results in the area of reducing this "oxidative stress". Some other things you should note, Protandim currently has 9 peer reviewed published studies (viewable at pubmed.gov) http://miniurl.com/PubMed/ and other medical universities along with the US Dept of Defense, are conducting self funded studies using Protandim to ascertain how the "proven reduction in Oxidative Stress" affects each of the diseases that these facilities are studying. The studies include skin cancer, diabetes, heart disease (Am heart assoc), metabolic syndrome, altitude sickness (Navy seals), muscular dystrophy, muscular sclerosis, fatty liver disease, heart bypass graft, renal failure, macular degeneration, asthma, and more.